In vitro fertilization (IVF) is a fertility treatment that involves incubating a couple’s eggs and sperm together in a lab dish to help increase the chances of successful fertilization. Once the embryos are viable, they’re transferred back into the woman’s uterus, hopefully leading to pregnancy. But despite all the stress, reams of research, and lots of money being spent on IVF every year, IVF success rates are still not well defined. However, while IVF can have an astonishing success rate when performed by trained professionals, there are several factors that can have an impact on whether or not it will be successful. Mothers Worlds is an IVF center in New Delhi that also believes in the following factors that impact the IVF success.
According to an Indian Express article, figures taken from the national registries in 36 European countries state that: “The IVF success rate has peaked, with one in six resulting in pregnancy.”
The Top 10 Factors Affecting IVF Success And Failure
While every couple is different and fertility issues can have many different causes, there are some general factors that can affect IVF success . These factors include reproductive age, uterine receptivity, and the number of injected oocytes, among many others. Considering each one, you may be more likely to achieve a successful pregnancy.
Read on to learn more. Hopefully, this article will give you a better understanding of some of the most important aspects of the process as considered by Mothersworlds, an infertility center in Delhi.
Reproductive Age
While the results of assisted reproductive technology are very accurate, the likelihood of conception is also affected by the fecundity of a couple.
In women, reproductive age increases the likelihood of multiple embryo replacements, which decreases live birth rates in later years. The older a woman is, the less viable her eggs will be. Women in their 20s have a much better chance of having a successful IVF procedure than women in their 40s. Thus, the highest success rates at Mothersworlds, an IVF center in New Delhi, were reported in women under 35 years of age. The rate of live birth per cycle in women under this age ranged between six and nine percent. After six cycles, the cumulative live birth rate ranged between 69% and 91%. The rates were slightly lower in women aged 30-34 and 44. Among women aged 45 and up, the rate per cycle was 11%, and the cumulative live birth rate ranged from twenty-three to forty-four percent.
Other concerns connected to reproductive age are:
- Fertilization rate
- Financial and mental counseling
- Chances of getting pregnant
In men, sperm chromosome abnormalities are less important than the frequency of intercourse, so older men are less likely to get pregnant than younger women.
Environment and Diet
The environment and diet for IVF success are important for both the woman and the man undergoing the procedure. While there are some general guidelines that should be followed, each individual’s specific needs will vary. For example, men should limit their intake of alcohol and soda and eat a diet rich in fruits and vegetables. These foods contain high levels of sugar, which is bad for the body and bad for the embryo. Diets rich in processed meats, preservatives, and fillers should be avoided. Protein-rich foods such as fish, poultry, and eggs are ideal, as they contain healthy fats and protein.
Stress and IVF Success: Too much stress can affect pregnancy. For this reason, patients are advised to limit their physical activities and maintain a healthy BMI during the treatment. In addition, exercise should be limited to light jogging or walking. Runners should avoid running for at least 20 km a week, as it can be extremely stressful on the body. If you are a serious runner, try light jogging, walking, or cycling instead.
A high-protein, low-sugar diet may improve the chances of pregnancy through IVF. The typical American diet is high in carbohydrates, and this has been shown to increase inflammatory markers like C-reactive protein (CRP). Researchers believe that high-sugar diets are not healthy for a woman’s body or a baby’s growth. High sugar levels are also not good for gametes or embryos, so a low-carb diet may be a good choice for a couple undergoing IVF. Environmental factors like the level of pollution, amount of caffeine consumed, and diet have been shown to have a significant effect on the IVF success.
Quality of eggs and sperm
To maximize the chances of success with IVF, egg quality is a critical factor in the process. Egg quality is based in part on ovarian reserve. While the number of eggs can be a good indicator, the quality of an egg can be just as important. Egg quality is a complex issue, as the higher its quality, the greater the chance that the embryo will implant in the uterus and develop into a viable baby.
A woman’s age is also a big factor in the number of eggs she has in her ovaries. When a woman is in her 20’s, she may have upwards of 20 eggs in her ovaries, but by the time she reaches her 30s, that number might have dropped to as low as five.
On the contrary, one of the major factors that influences the success or failure of IVF is the quality of sperm in men. Sperm quality is one of the major contributing factors to infertility in men. It is estimated that about 40% of male fertility problems can be attributed to male factors. A sperm analysis determines the potential for pregnancy by checking density, motility, shape, and morphology. High-quality sperm can increase the chances of IVF success.
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Timing of embryo transfer
The right timing is of crucial importance to the IVF success. It’s best to transfer the embryo as close to the time of ovulation as possible to give it the best chance of implanting in the uterine wall.
IVF procedure used
The type of IVF procedure used will also impact the chances of a successful pregnancy. Certain procedures, like ICSI and GIFT ( Gamete Intrafallopian Transfer), can increase the rate of success, while others, like IVF with GIFT, can be more invasive and riskier.
The number of injected oocytes
The number of injected oocytes can affect the IVF success or failure rate. The number of injected oocytes was higher in ICSI than in IVF, with a statistically significant difference between the two methods. For both treatments, the number of MII oocytes needed to produce a viable blastocyst was significantly lower with ICSI.
Addiction
Although it may seem impossible to change a person’s habits, addictions to prescription drugs, illicit substances, and even smoking can negatively affect a woman’s ability to conceive. While these effects are generally temporary once the individual stops using the chemical substances, they can permanently alter a woman’s ability to conceive. For this reason, Mothersworld, the best IVF Center in New Delhi, counsels women who may be at risk for complications during IVF treatment and encourages them to put an end to the unhealthy lifestyle that is affecting their ability to conceive.
Uterine receptivity
The quality of an embryo is crucial to IVF success, but uterine receptivity is just as critical. If the seed is unhealthful, or the soil is not receptive, the odds of embryo implantation are low. Various factors can affect a woman’s receptivity, including the thickness of her uterine lining, the immunological makeup of her uterus, and the contour of her uterus.
Embryo cryopreservation
There are two major concerns with cryopreservation: decreased viability and increased oxidative stress. Both of these issues can lead to a reduced reproductive outcome. This is why it is essential to avoid embryo cryopreservation whenever possible. However, the advantages of this method outweigh these negatives. The following are the most important reasons why embryo cryopreservation is a poor choice:
Female reproductive health conditions
Finally, a female’s reproductive health is also a significant factor in IVF success. Diseases like endometriosis or polycystic ovary syndrome (PCOS) can decrease the chances of IVF working.
Conclusion
The IVF success or failure of IVF procedures can vary from couple to couple and from woman to woman. While only a small percentage of patients will not become pregnant after IVF treatment at the best IVF center in Delhi, Mothers Worlds Still, there are a number of factors that can make IVF success less likely. Couples undergoing IVF are encouraged to be as healthy as possible and to be patient as the process can often take several attempts before a successful pregnancy occurs.
IVF is expensive, time-consuming, and emotional. Patients often go through several cycles of the procedure, each costing thousands of dollars. However, Mothersworld, an infertility centre in Delhi, offers rebates for some of these costs, and private health funds may cover other costs under certain conditions. The cost of IVF treatments in Delhi includes medications, tests, and day surgeries.